comminution UK /ˌkɒmɪˈnjuːʃ(ə)n/US /ˌkɑməˈn(j)uʃən/ noun2 •The breaking or grinding up of a material to form smaller particles.What circumstances determine the degree of comminution to which a substance should be subjected preparatory to future extraction? — 1873 •The fracture of a bone site into multiple pieces (at least three, and often many).Comminution of the shaft of one or of both bones of the fore-arm does not of itself indicate operative interference, other complications may necessitate primary or secondary amputation. — 1851 formscomminutions