cimetidine /saɪˈmɛt.ɪ.diːn/ noun1 •A histamine H₂-receptor antagonist that inhibits the production of acid in the stomach, mainly used to treat heartburn and peptic ulcers, but notorious for causing male impotence. It is a histamine analog, a sulfur-containing derivative of imidazole.Until Tagamet (cimetidine), most major drug companies didn't take tummy troubles terribly seriously. — 1985 formscimetidines