chromo /ˈkɹəʊməʊ/adjective 1noun 2forms 1 adjective1 •Of or relating to the chromodomain, a protein structural domain associated with chromatin productionTo determine whether the conserved domains, the chromo, SET, and cysteine-rich regions, were also critical for Clr4 HMTase activity, we tested mutant Clr4 proteins for HMTase activity. — 2001 noun2 •(historical) A color print produced by chromolithography.All Nature is smiling, in fact, with one large, comprehensive smile, exactly like a first-class PRANG chromo with a fresh coat of varnish upon it. — 1870 •(Australia) A prostitute.That dried-up lady snob lived behind lace curtains all her life. She's of no more importance than a chromo. — 1970 formschromos