Chicago UK /ʃɪˈkɑː.ɡəʊ/US /ʃɪˈkɑ.ɡoʊ/ noun2 •A large city, the county seat of Cook County, in northeastern Illinois, United States, located on Lake Michigan.Chicago is now #1 in murder and sausages. That sounds like my kind of town! — 2014 •Any of various forms of the game of pool, designed for gambling.