centromere UK /ˈsɛntɹə(ʊ)mɪə/US /ˈsɛntɹəˌmiɚ/ noun1 •The central region of a eukaryotic chromosome where the kinetochore is assembled.Every chromosome has a long arm and a short arm separated by a pinch point known as a centromere. — 1999 formscentromeres