calculus UK /ˈkæl.kjʊ.ləs/US /ˈkæl.kjə.ləs/ noun6 •Any formal system in which symbolic expressions are manipulated according to fixed rules. •Differential calculus and integral calculus considered as a single subject.I took calculus in high school. •A decision-making method, especially one appropriate for a specialised realm.The Tory leader refused to state how many financiers he thought should end up in jail, saying: “There is not some simple calculus." — 2008 •(old-fashioned) Calculation; computation. •A stony concretion that forms in a bodily organ. •Deposits of calcium phosphate salts on teeth. formscalculi · calculuses