butthole /ˈbʌtˌhoʊl/ noun3 •(slang, vulgar) The anus.My butthole is on fire from that dang hot sauce of yours. •(US, offensive) An objectionable person; a bastard; a jerk.Don't be such a butthole. •(informal, disapproving) An unpleasant or undesirable place. formsbuttholes