bupropion UK /bjuːˈpɹəʊ.pi.ən/US /bjuːˈpɹoʊ.piˌɑn/ noun1 •An antidepressant drug which is also given to relieve the symptoms of nicotine withdrawal.A common solution is switching to bupropion, which is a norepinephrine-dopamine reuptake inhibitor, or NDRI. — 2024