both-handedness noun2 •Ambidexterity.Until recently, and even now, both-handedness (ambidextrousness) has been mentioned as a cause of reading difficulties rather than seen as an indicator of immaturity. — 2012 •The property of involving two sides, approaches, or orientations.Serving God with one hand and the devil with the other is a style of both-handedness from which we may well pray to be saved. — 1867