bestie /ˈbɛsti/noun 3forms 1phrases 1 noun3 •(informal) A best friend.You're supposed to be my bestie, Mel. We used to tell each other everything. So what's this Toby secret you can't tell me? — 2007 •(informal) A friend (any in general). •(informal) A term of address for someone, usually used to instruct, to make a statement, or to draw attention. formsbesties Phrases with bestie so true, bestieAn assertion that something is true or relatable.