backbone UK /ˈbækˌbəʊn/US /ˈbækˌboʊn/noun 3forms 1phrases 1 noun3 •The series of vertebrae, separated by disks, that encloses and protects the spinal cord, and runs down the middle of the back in vertebrate animals. •(figurative) Any fundamental support, structure, or infrastructure.Before automobiles, railroads were a backbone of commerce. •(figurative) Courage, fortitude, or strength.He would make a good manager, if he had a little more backbone. formsbackbones Phrases with backbone to the backboneThrough and through; thoroughly; entirely.