annihilate /əˈnaɪ.ə.leɪt/ verb5 •To reduce to nothing, to destroy, to eradicate.An atom bomb can annihilate a whole city. •To render null and void; to abrogate. •To react with antimatter, producing gamma radiation and (for higher-mass reactants, especially composite particles such as protons) lighter particles (such as pions, muons, and neutrinos). •To cause to become zero by means of an annihilator operator. •(no longer used) To treat as worthless, to vilify.of all the opinions which Antiquity hath had of men in gross, those which I most willingly embrace, and whereon I take most hold, are such as most vilifie, condemne, and annihilate us. — 1603 formsannihilated · annihilating · annihilates · annihilateth