a pox on

exclamation2

1. •
   (humorous) To hell with (abstract or unalive things).

   • A pox of that jest! and I beshrew all shrows. — 1595
2. •
   (offensive, no longer used) To express curses upon (somebody), when irked or wroth, as though wishing someone "a pox".

   • A pox o' your throat, you bawling, blasphemous, incharitable dog! — 1610