zeptomole UK /ˈzɛptəʊˌməʊl/US /ˈzɛptoʊˌmoʊl/ noun1 •10⁻²¹ mole, or about 600 molecules. SI symbol: zmol.It has been repeatedly shown that enzyme-derived ODN-based assays can detect as little as 50 zeptomoles of target DNA corresponding to about 25,000 molecules. — 2002 formszeptomoles