what's your poison UK /ˌwɒts jə ˈpɔɪz(ə)n/US /ˌ(h)wʌts jəɹ ˈpɔɪz(ə)n/ phrase1 •(informal, old-fashioned) Used to someone what alcoholic beverage they would like to drink: what drink would you like to have?What's yer poison, darlin'? — 1998