vital signs noun[plural only]2 •A set of measurements of a patient's condition taken regularly to assess the state of bodily functions: CSM, skin signs, lung sounds, temperature, pulse, blood pressure, and respiration.Read between the lines / What's fucked up, and everything's alright / Check my vital signs / To know I'm still alive, and I walk alone — 2004 •(figurative) A set of variables or characteristics that indicate the general condition of something.the vital signs of the economy