turn upside down

verb3

1. •
   To flip over; to rotate top to bottom.

   • Turn the box upside down and look at the bottom.
2. •
   To alter (something) significantly, often in a negative way.

   • Rio Ferdinand will almost certainly miss out on Euro 2004, and possibly much more, because of the missed drug test which has turned his life upside down. — 2003
3. •
   To thoroughly examine.

   • They turned the house upside down looking for the car keys.