trypanosome noun5 •Any of a group of protozoan parasites which are transmitted by biting insects and infect the blood of humans and other vertebrates; family Trypanosomatidae in class Kinetoplastea •Any member of the genus Trypanosoma, of family Trypanosomatidae. •Trypanosoma brucei, a major human pathogen that causes sleeping sickness. •Trypanosoma cruzi, a major human pathogen that causes Chagas disease. •Trypomastigotes, a morphological class of trypanosomatids with a flagellum laterally attached to the cell body. formstrypanosomes