Trump derangement syndrome noun2 •(informal, disapproving) Irrationally negative reactions to the actions and policies of US President Donald Trump."Some people HATE the fact that I got along well with President Putin of Russia," he tweeted. "They would rather go to war than see this. It's called Trump Derangement Syndrome!" — 2018 •(informal, disapproving) Irrationally rabid support for US President Donald Trump.“This is what Trump Derangement Syndrome really is,” Maher explained. “Pretending that all of this is perfectly acceptable behavior for an American president.” — 2019