trihexyphenidyl UK /ˌtɹʌɪ.hɛk.sɪˈfɛn.ɪ.dʌɪl/US /tɹaɪˌhɛk.sɪˈfɛn.ɪˌdɪl/ noun1 •An antimuscarinic drug that has an antispasmodic action on smooth muscle and is used to treat parkinsonism and some other movement disorders.