thrombospondin UK /ˌθɹɒm.bə(ʊ)ˈspɒn.dɪn/US /ˌθɹɑm.boʊˈspɑn.dɪn/ noun1 •Any of a family of glycoproteins secreted into the extracellular matrix by various types of cell, which play a role in cellular adhesion in processes including thrombocyte aggregation, tumor metastasis, and angiogenesis. formsthrombospondins