thiamazole UK /θʌɪˈam.ə.zəʊl/US /θaɪˈæm.əˌzoʊl/ noun1 •An imidazole derivative that interferes with the synthesis of thyroid hormone and is given orally in the treatment of hyperthyroidism; 1-methylimidazole-2-thiol, C₃H₂N₂(CH₃)(SH).