take up with verb4 •To form a close relationship with (someone).I hear that John has taken up with Jane. •To become interested in (something).It seems, then, that automobiles and automobiling were on Walter Chrysler's mind for a long time before he took up with this legendary Locomobile — 2001 •To begin living together with; to lodge with. •(no longer used) To be contented to receive; to receive without opposition; to put up with. formstook up with · taken up with · taking up with · takes up with