take a powder verb1 •(US, informal) To leave without saying goodbye; to leave quietly, to run away; to scram; to depart without taking leave or notifying anyone, often with the implication of avoiding something unpleasant or shirking responsibility.Macdonald spoke slowly, bitterly. "The kidnapping is one too many for me, Costello. I don't want any part of it. I'm takin' a powder from this toy mob. I took a chance that bright boy might side me." — 1933 formstook a powder · taken a powder · taking a powder · takes a powder