sulphamethoxazole UK /ˌsʌl.fə.mɪˈtɒk.sə.zəʊl/US /ˌsʌl.fəˌmɛˈθɑk.səˌzoʊl/ noun1 •An antibacterial sulfonamide C₁₀H₁₁N₃O3S used alone or in combination with trimethoprim (as in the treatment of urinary tract infections or acute otitis media).