sucralfate UK /ˈs(j)uː.kɹəlˌfeɪt/US /suˈkɹælˌfeɪt/ noun1 •A drug used in the treatment of gastric and duodenal ulcers. It is a complex of aluminium hydroxide and a sulfate derivative of sucrose, C₁₂HₘAl₁₆OₙS₈ where m and n are approximately 54 and 75.