southpaw /ˈsaʊθˌpɔː/ noun3 •(informal) One who is left-handed, especially in sports. •(informal) A left-handed pitcher.Since home plate is generally in the southwest corner to avoid glare in the batter's eyes, a southpaw's pitching hand is to the south. •(informal) A boxer who leads with the right hand and guards with the left. formssouthpaws