smoke up verb6 •To fill with smoke. •(informal) To smoke, and get the effects from, a drug, especially marijuana.Oh baby, baby, have you seen Amy tonight? / Is she in the bathroom, is she smokin' up outside? — 2008 •(informal) To provide the resources for another to smoke, especially marijuana.He usually smokes me up, so I smoked him up last night. •To become filled with smoke. •To cook by smoking. •To smoke all of one's supplies. formssmoked up · smoking up · smokes up