sickle cell trait noun1 •A genotype, and the carrier state constituted by it, that is the heterozygous counterpart to sickle-cell disease (which involves a homozygous hit). It is not classified as a disease entity because it usually has little clinical effect (generally asymptomatic).I learned from her that I carried the sickle cell trait, which meant I would never be sick, but my child could be, if my husband also carried the trait. — 2005
