selective serotonin reuptake inhibitor noun1 •Any of a class of drugs, such as fluoxetine or sertraline, that inhibit the uptake of serotonin in the central nervous system and are often used to treat certain mental illnesses, such as depression.Common types of treatment for depression include the selective serotonin reuptake inhibitors (SSRIs) and the tricyclic antidepressants. — 2006 formsselective serotonin reuptake inhibitors
