screw over verb1 •(slang, vulgar) To cheat someone, or ruin their chances in a game or other situation.I would have won the game but you screwed me over when I landed on Mayfair.If you didn't betray your most reliable ally just so you could win in a game of soccer, you wouldn't have screwed yourself over by getting reprimanded and disqualified in front of everyone. formsscrewed over · screwing over · screws over