Santa Fe /ˌsæntə ˈfeɪ/ noun3 •The capital city of New Mexico and the county seat of Santa Fe County.The couple’s stucco, Pueblo-revival style home sits on a hill in a gated community at the southern tip of the Rocky Mountains. Santa Fe is known as a refuge for celebrities, artists and authors. — 2025 •A province in the center-east of Argentina. •The capital city of the province of Santa Fe, Argentina; in full, Santa Fe de la Vera Cruz.