Santa Cruz noun 9 noun9 •The capital city of Tenerife, Canary Islands, Spain; in full, Santa Cruz de Tenerife. •A department in eastern Bolivia. •A province of Patagonia, Argentina. •A municipality, the capital of Laguna, Calabarzon, Philippines. •A canton of Guanacaste Province, Costa Rica. •A district and town, the capital city of Santa Cruz canton, Guanacaste province, Costa Rica. •A canton of Galapagos province, Ecuador. •A province of Cajamarca department, Peru. •[plural only] The native people from the Santa Cruz area of California.