Santa Clara UK /ˌsæn.tə ˈklɑː.ɹə/US /ˌsæn.tə ˈklɛɚ.ə/adjective 1noun 1 adjective1 •Of or pertaining to the Santa Clara Pueblo people, culture, or the variety of Tewa they speak. noun[plural only]1 •A federally recognized tribe of Tewa-speaking Pueblo people in Rio Arriba County, New Mexico.