rosiglitazone /ɹoʊ.sɪˈɡlɪt.əˌzoʊn/ noun1 •A thiazolidinedione derivative (trademark Avandia) taken orally in the form of its maleate C₁₈H₁₉N₃O₃S·C₄H₄O₄ to treat type 2 diabetes by decreasing insulin resistance.