Rio Grande /ˌɹiːoʊˈɡɹænd/ noun1 •A major river in the United States and Mexico, starting in Colorado, flowing through New Mexico, and forming the boundary between Texas and the Mexican states of Chihuahua, Coahuila, Nuevo León and Tamaulipas for most of its length.When Mexico gained its independence from Spain, the new country also obtained control over the lands North of the Rio Grande River that had been previously held by the Spanish. — 1991