propylthiouracil UK /ˌpɹəʊ.pʌɪl.θʌɪ.əʊˈjʊə.ɹə.sɪl/US /ˌpɹoʊ.pəlˌθaɪ.oʊˈjʊɹ.əˌsɪl/ noun1 •A thioamide drug, used to treat hyperthyroidism by decreasing the amount of thyroid hormone produced by the thyroid gland, which is associated with a risk of agranulocytosis.