procainamide UK /pɹəʊˈkeɪ.nəm.ʌɪd/US /pɹoʊˈkeɪ.nəˌmaɪd/ noun1 •A base of an amide related to procaine (trademark Pronestyl) that is used in the form of its hydrochloride C₁₃H₂₁N₃O·HCl as a cardiac depressant especially in the treatment of ventricular and atrial arrhythmias.