picture frame UK /ˈpɪktʃə ˌfɹeɪm/US /ˈpɪkt͡ʃɚ ˌfɹeɪm/ noun1 •The frame into which a picture is placed.He pulled a picture frame to one side, revealing a safe behind. Chang pressed four buttons on the keypad… …and the safe door whirred open. — 2017 formspicture frames