physostigmine UK /ˌfʌɪ.səʊˈstɪɡ.miːn/US /ˌfaɪ.səˈstɪɡˌmin/ noun1 •A parasympathomimetic, a reversible cholinesterase inhibitor alkaloid of the Calabar bean, used to treat certain medical conditions. formsphysostigmines