pathogenesis UK /ˌpæθ.ə(ʊ)ˈd͡ʒɛn.ə.sɪs/US /ˌpæθ.oʊˈd͡ʒɛn.ə.sɪs/ noun2 •The origin and development of a disease. •The mechanism whereby something causes a disease. formspathogeneses