paromomycin UK /ˌpa.ɹəʊ.məʊˈmʌɪ.sɪn/US /ˌpæɹ.əm.oʊˈmaɪ.sn̩/ noun1 •A mixture of broad-spectrum aminoglycoside antibiotics related to neomycin and produced by some strains of the bacterium Streptomyces rimosus, given orally in the form of the sulfate C₂₃H₄₅N₅O₁₄·H₂SO₄ in the treatment of intestinal amebiasis.