paranoia /ˌpæɹ.əˈnɔɪ.ə/ noun2 •Extreme, irrational distrust of others. •(no longer used) A psychotic disorder, now called delusional disorder, often (in one of six subtypes) characterized by delusions of persecution and a perceived threat against the individual affected with the disorder, and often associated with false accusations and a general mistrust of others. formsparanoiae · paranoias