oppo UK /ˈɒ.pəʊ/US /ˈɑ.poʊ/ noun2 •(US, informal) Research into one's opponent's family, friends, and past, which aims to uncover activities or interests which embarrass or discredit them. •(UK, slang) A friend, associate or colleague.'I suppose you're referring to Fluker,' I told him, and he looked at me in stunned amazement when I explained that he was one of my old oppoes. — 2012 formsoppoes · oppos