ondansetron UK /ɒnˈdæn.sə.tɹɒn/US /ɑnˈdæn.səˌtɹɑn/ noun1 •A carbazole derivative (trademark Zofran), C₁₈H₁₉N₃O, that is a serotonin receptor antagonist administered by injection and by mouth to relieve nausea and vomiting, especially during cancer therapy.