nitrofurantoin UK /ˌnʌɪ.tɹə(ʊ).fjʊˈɹan.təʊ.ɪn/US /ˌnaɪ.tɹoʊ.fjʊˈɹæn.toʊ.ɪn/ noun1 •A synthetic nitrofuran drug, 1-(5-nitro-2-furfurylideneamino)hydantoin, that is a broad-spectrum antimicrobial agent used in the treatment on urinary tract infections such as cystitis.