Mona Lisa UK /ˌməʊnə ˈliːzə/US /ˌmoʊnə ˈlisə/ noun2 •(figurative) A masterpiece, an outstanding work.I told him I didn't care if the painting was a Mona Lisa or pure nonsense, I just wanted him to have the experience of painting on canvas. — 2007 •(figurative) A woman who resembles the subject of this painting, renowned for her beauty and enigmatic smile.She let him take it and sat on, smiling very faintly. It was a Mona Lisa effort. — 1972 formsMona Lisas