metformin UK /mɛtˈfɔː.mɪn/US /mɛtˈfɔɹ.mɪn/ noun1 •A biguanide derivative, C₄H₁₁N₅, used, now chiefly as the hydrochloride, as an oral hypoglycemic agent in the treatment of type 2 diabetes mellitus; 1,1-dimethylbiguanide. formsmetformins