mess with verb4 •(informal) To interfere with.Don't mess with the controls. I just got everything adjusted correctly. •(informal) To joke around with or dupe someone, in either a friendly or unfriendly manner.Don't worry: I'm just messing with you. •(informal) To diss; to put down.Hey! Quit messing with my brother. •(informal) To admire, enjoy, or approve of.You know I mess with you heavy. formsmessed with · messing with · messes with