mercaptopurine UK /mɜːˌkap.tə(ʊ)ˈp(j)ʊə.ɹiːn/US /mɚˌkæp.təˈpjʊɹˌin/ noun1 •An thiol antimetabolite C₅H₄N₄S that interferes especially with the metabolism of purine bases and the biosynthesis of nucleic acids and that is sometimes used in the treatment of acute leukemia. formsmercaptopurines